Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
نویسندگان
چکیده
From Christie Hospital, Manchester (J.V.); Hammersmith Hospital, Imperial College Health Care Trust (H.W.), Royal Marsden Hospital (D.C.), Cancer Research United Kingdom and University College London Cancer Trials Centre (S.H., M.R.), Institute of Hepatology, University College London (S.P.P.), and University College London Cancer Institute (J.B.) — all in London; University Hospital Birmingham, Birmingham (D.H.P.); St. James’s Hospital, Leeds (A.A.); Castle Hill Hospital, Hull (A.M.); Nottingham University Hospitals, Nottingham (S.M.); and Southampton University Hospitals, Southampton (T.I.) — all in the United Kingdom. Address reprint requests to Dr. Bridgewater at the University College London Cancer Institute, 72 Huntley St., London WC1E 6AA, United Kingdom, or at [email protected].
منابع مشابه
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Evaluation of: Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362, 1273-1281 (2010). Biliary tract cancer is a rare disease and it is associated with a poor clinical outcome and survival. A standard therapy has not been established yet. The evaluated article reports on the first Phase III randomized controlled multicen...
متن کاملTargeted Therapy for Biliary Tract Cancer
It is necessary to establish effective chemotherapy to improve the survival of patients with biliary tract cancer, because most of these patients are unsuitable candidates for surgery, and even patients undergoing curative surgery often have recurrence. Recently, the combination of cisplatin plus gemcitabine was reported to show survival benefits over gemcitabine alone in randomized clinical tr...
متن کاملPhase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma.
OBJECTIVES The prognosis for patients with unresectable biliary tract cancer is poor and existing chemotherapy is relatively ineffective. Therefore, a need exists for new, effective chemotherapeutic regimens. The aim of this study was to determine the efficacy and safety profile of gemcitabine plus cisplatin in patients with unresectable biliary tract cancer (cholangiocarcinoma) and gall bladde...
متن کاملRandomized phase II study of gemcitabine plus S-1 combination therapy vs. S-1 in advanced biliary tract cancer: Japan Clinical Oncology Group Study (JCOG0805).
A randomized Phase II selection design trial comparing gemcitabine plus S-1 combination therapy with S-1 monotherapy for chemo-naïve unresectable or recurrent biliary tract cancer patients was started in Japan. The aim of this trial is to evaluate the efficacy and safety of the two regimens and to determine which is more promising as a test arm regimen to be compared with the current standard r...
متن کاملCisplatin/gemcitabine or oxaliplatin/gemcitabine in the treatment of advanced biliary tract cancer: a systematic review
Cisplatin/gemcitabine association has been a standard of care for first-line regimen in advanced biliary tract cancer nevertheless oxaliplatin/gemcitabine regimen is frequently preferred. Because comparative effectiveness in clinical outcomes of cisplatin- versus oxaliplatin-containing chemotherapy is not available, a systematic review of studies assessing cisplatin/gemcitabine or oxaliplatin/g...
متن کاملThe Hepatobiliary and Pancreatic Oncology (HBPO) Group of the Japan Clinical Oncology Group (JCOG): history and future direction.
The Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG) was constituted in April 2008 to develop new standard treatments for hepatobiliary and pancreatic cancer. In pancreatic cancer, the Hepatobiliary and Pancreatic Oncology Group focuses on establishing standard chemotherapy or chemoradiotherapy for unresectable locally advanced disease. The JCOG 0506 study...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010